… In summary, we have developed a murine vaccine strategy that employs HK-fbp1 as an
effective vaccine strain against multiple invasive fungal infections in both immunocompetent and …

… Invasive fungal infections are primarily caused by … investigate the efficacy of host protection
after vaccination with either live or … tested our vaccination strategy in this mouse model during …

… to elicit robust host protection against cryptococcosis. … strain but also against additional
invasive fungal infections, … Therefore, we further examined the potential vaccine protection in mice …

… in mice. Our findings showed that treatment of mice with a … -immunizing model mice
with a heat-killed prm1Δ strain greatly … and potential vaccinations against fungal infections. …

… to be instrumental in host protection against C. neoformans. … our lab has developed a mouse
model of cryptococcosis that … , and that live but not heat killed cells were necessary for this …

… FIG 1 Vaccination with heat-killed ZNF2 oe cells protects … mortality in mice in the inhalation
infection model of cryptococcosis … As live strains are more effective in providing host protection …

… , we investigated the effect of the vaccination strategy in a TLR2 −/− mouse model. We found
that γδ … shown that heat-killed (HK) C. neoformans Δsgl1 provided full host protection during …

… neoformans strain H99 or H99-γ or heat-killed C. neoformans … neoformans strain H99
using the mouse inhalational model. As … fungal infections such as cryptococcosis can result in …

… the vaccination dose of heat-killed wild-type H99 would also offer host protection. … recognized
by the anti-cryptococcal cell-mediated immune response in mice (45, 46). For example, …

… that Cryptococcus neoformans Δsgl1, a mutant strain that … in a mouse model of infection
and conferred complete host … conferred complete host protection against the WT strain, we …